在患有慢性阻塞性肺病的患者中,逆流食道炎和肺功能之间的关联
Huanyu Qian1, Lixia Wang1, Jie Xu2
1The Second Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Journal of thoracic disease
|November 18, 2024
概括
逆流性食道炎 (RE) 在患有慢性阻塞性肺病 (COPD) 的患者中损害肺功能. 然而,RE的严重程度与COPD的严重程度没有相关性,这表明了不同的病理生理路径.
科学领域:
- 肺部病理学 肺部病理学
- 胃肠病学 胃肠病学
- 内部医学 内部医学
背景情况:
- 胃食道逆流性疾病 (GERD) 与慢性阻塞性肺部疾病 (COPD) 有关.
- 逆流食道炎 (RE) 与慢性肺炎 (COPD) 之间的特定关系,特别是它对肺功能的影响,需要进一步研究.
研究的目的:
- 研究慢性阻塞性肺病 (COPD) 患者的逆流食道炎 (RE) 和肺功能之间的关联.
- 阐明RE和COPD之间关于肺功能参数的相互作用.
主要方法:
- 一项队列研究涉及2021年4月至2023年10月期间接受肺功能测试 (PFT) 和内镜检查的患者.
- 收集的数据包括人口学变量,PFT结果 (FEV1,FEV1/FVC,MMEF75/25,ERV,PEF) 和内镜检查结果.
- 使用SPSS进行统计分析,在P<0.05.05时确定显著性.
主要成果:
- 与没有RE的患者相比,COPD和RE的患者在FEV1,FEV1/FVC,MMEF75/25,ERV和PEF中显示出显著的差异.
- 在RE和COPD严重程度之间没有发现统计学意义上的关联.
- 在研究的队列中,RE与COPD严重程度没有相关性.
结论:
- 逆流性食道炎 (RE) 在患有或没有慢性阻塞性肺病 (COPD) 的个体中导致肺功能减弱.
- 没有观察到COPD的严重程度和RE的存在之间的相互作用.
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