阻塞性睡眠呼吸暂停和心血管疾病:前性研究的系统审查和元分析
Shwan Amen1, Banan Rasool2,3, Bareq S Al Lami4
1Cardiac Center, Surgical Specialty Hospital, Erbil, IRQ.
Cureus
|November 18, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 是常见的,与心血管疾病 (CVD) 有关. 这次审查没有找到明确的证据表明OSA增加心血管疾病风险,但早期治疗,如CPAP可能有所帮助. 需要进一步的研究.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 阻塞性睡眠呼吸暂停 (obstructive sleep apnea,OSA) 是一种广泛的疾病,在睡眠期间导致呼吸暂停.
- 人们怀疑OSA会增加心血管疾病 (CVD) 的风险,但这种联系尚未完全理解.
研究的目的:
- 系统地审查和元分析前性研究,评估OSA和心血管结果之间的关联.
- 综合目前关于OSA与高血压,冠状动脉疾病和心力衰竭等疾病之间关系的证据.
主要方法:
- 在主要数据库 (PubMed,Scopus,Cochrane Library) 中使用PRISMA指南进行了系统的文献搜索.
- 来自12项前性研究的数据使用随机效应模型进行了分析,评估了各种心血管结果.
- 研究质量使用纽卡斯尔-太华尺度 (NOS) 进行评估.
主要成果:
- 与OSA相关的心血管事件的汇总相对风险为0.79 (95% CI:0.56-1.03),表明风险降低的趋势不显著.
- 观察到显著的异质性,研究报告了心血管风险的增加和减少.
- 小组分析没有改变整体不显著的发现,未能确立明确的因果关系.
结论:
- 目前的元分析没有证实OSA和心血管风险增加之间存在因果关系.
- OSA和CVD之间的复杂关联需要对潜在机制进行进一步的研究.
- 建议进行常规的OSA查和CPAP治疗等干预措施,以潜在地减轻心血管风险.
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