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肠道微生物组在人类乳腺增生症:从诊断到发现的组成和抗体动力学

Soumi Chowdhury^1,2, Robert F J Kullberg³, Bastiaan W Haak^3,4

¹Department of Microbiology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.

Open forum infectious diseases

|November 18, 2024

概括

梅里欧症显著改变了患者的肠道微生物群和抗菌素耐药性 (AMR) 基因. 这些变化在治疗后仍然存在,这凸显了恢复肠道健康的干预措施的必要性.

科学领域:

微生物学微生物学
人类微生物组研究研究
传染性疾病传染性疾病

背景情况:

由*Burkholderia pseudomallei*引起的性疹是一种全球性的健康问题,需要长时间的抗生素治疗.
之前在小鼠身上进行的研究表明肠道微生物群会影响乳腺炎的传播,但人类肠道微生物群在感染期间仍然没有表征.
这项研究旨在表征肠道微生物群和抗微生物药物耐药性 (AMR) 基因在人类有机粉症患者.

研究的目的:

纵向表征肠道微生物组合和AMR基因的特征. 在有机症患者中.
为了比较肠道微生物群和AMR档案的有机症患者与社区对照.
为了调查肠道微生物群变化与美利欧症期间的二次感染之间的关联.

主要方法:

一项前性观察队列研究,涉及印度一家三级护理医院住院的乳腺炎患者.
在诊断时,治疗期间和感染后6个月收集便样本;社区成员作为对照.
枪支元基因组测序用于描述肠道微生物群组成和抗体 (AMR基因).

主要成果:

与对照人群相比,梅里欧症患者在诊断时表现出明显的肠道微生物群,病原性细菌增加,酸盐生产者减少,AMR基因升高.
在感染后6个月内,肠道微生物群和抗体仍然存在变化,受累积抗生素暴露的影响.
与住院相关的肠道微生物群概况与二次 *Klebsiella肺炎* 感染相关.

结论:

这是第一个研究表明显著的肠道微生物群和抵抗性干扰在人体菌症.
在住院期间,微生物群的变化很大,感染后6个月恢复有限.
缓解微生物群破坏或促进恢复的干预措施,如产生酸盐的益生菌,可能会改善结果.

关键词:

其他AMR基因.印度印度印度我们的肠道微生物组.质性化症是什么一些抗体对抗.

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