在患有肥胖和2型糖尿病的人群中,区域原发性前脂肪细胞特征
Claire Plissonneau1,2,3, Sylvia Santosa1,2,3
1Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal, Quebec, Canada.
Heliyon
|November 18, 2024
概括
肥胖和2型糖尿病 (T2DM) 改变人体脂肪细胞. 本综述详细介绍了肥胖和T2DM中区域脂肪细胞特征的差异,影响疾病的发展.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 细胞生物学 细胞生物学
背景情况:
- 肥胖导致脂肪组织功能障碍,导致2型糖尿病 (T2DM) 等疾病.
- 人体脂肪组织储存 (皮下,内脏) 具有不同的微环境,影响前脂肪细胞功能.
- 虽然3T3-L1细胞系提供了洞察力,但初级人类前脂肪细胞研究对于理解肥胖和T2DM影响至关重要.
研究的目的:
- 来自肥胖个体的初级人类前脂肪细胞的区域差异的审查.
- 讨论这些前脂肪细胞特征是如何受到2型糖尿病的影响的.
- 突出肥胖和T2DM对区域人类前脂肪细胞表型的影响差异.
主要方法:
- 对原发性人类前脂肪细胞的现有文献的审查.
- 对比皮下和内脏脂肪组织储存的研究分析.
- 在肥胖和T2DM的背景下检查前脂肪细胞特征.
主要成果:
- 肥胖不同影响区域原发性人类前脂肪细胞的特征.
- 2型糖尿病进一步改变了这些区域前脂肪细胞表型.
- 肥胖和T2DM如何影响不同身体部位的脂肪细胞前体存在显著差异.
结论:
- 区域原发性前脂肪细胞特征是不同的,并由肥胖症调节.
- T2DM的发展加剧了人类前脂肪细胞的这些区域差异.
- 了解这些特定的变化是解决肥胖相关代谢疾病的关键.
关键词:
脂肪组织的脂肪组织.身体组成 身体组成人类 人类 人类 人类 人类炎症 炎症是一种炎症.肥胖问题 肥胖问题预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes 预adipocytes原始细胞主要是细胞.地区脂肪地区脂肪皮下脂肪组织的脂肪组织.2 型糖尿病 2 型糖尿病内脏脂肪组织的脂肪组织.相关概念视频
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