,WAVE1WAVE2

D J Fernandez1, Stephanie Cheng1, Ruben Prins1

  • 1Department of Molecular Microbiology & Immunology and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United States.

概括

威斯科特-阿尔德里奇综合征蛋白WAVE1和WAVE2对于人类乳头瘤病毒16型 (HPV16) 感染至关重要. 这些蛋白质调解了actin重组,促进HPV16通过filopodia形成进入上皮细胞.

相关概念视频

Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
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Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

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Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
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Actin Filament Depolymerization01:19

Actin Filament Depolymerization

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In F-actin, the ADF/cofilin proteins...
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Generation of Straight or Branched Actin Filaments01:14

Generation of Straight or Branched Actin Filaments

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Arp2/3 Complex
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