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Updated: Jun 7, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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替代拼接调节了RIF1 C终端域的染色体相互作用和相分离

Adenine Si-Hui Koo1, Weiyan Jia1, Sang Hwa Kim1

  • 1Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705, USA.

bioRxiv : the preprint server for biology
|November 18, 2024
PubMed
概括

RIF1 (RAP1相互作用因子) 的替代拼接会产生不同的变体,影响DNA修复和基因组组织. 细胞周期,DNA损伤和特定的剪接因子调节了exon 32的包含,影响了RIF1的功能.

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