赫普西丁在宿主对散播型 кандидоз耐药性的重要作用
bioRxiv : the preprint server for biology
|November 18, 2024
概括
肝素缺乏会通过促进真菌生长和菌根过渡来加剧侵入性Candida albicans感染. 像PR-73这样的肝素仿真剂在治疗这些危险感染方面表现有前途.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 铁的恒温是铁的恒温.
背景情况:
- *侵袭性 *Candida albicans* 感染导致高死亡率,特别是在住院患者中.
- * 慢性肝病增加了对候选血症的易感性,这与肝素的产生受损和铁的失调有关.
研究的目的:
- *阐明肝素缺乏症与C. albicans感染易感性之间的机制联系.
- * 调查肝素模仿剂在治疗侵袭性 кандидоз的治疗潜力.
主要方法:
- *利用遗传和诱导性肝素淘汰赛的小鼠模型.
- * 评估了真菌负担,形态 (甲状腺过渡) 和宿主损伤.
- * 在感染模型中评估了肝素模仿剂 (PR-73) 的疗效.
主要成果:
- * 肝素缺乏导致无节制的真菌生长和增加状细胞的发育.
- * 暴露于中β-葡萄糖加剧了损伤,独立于candidalysin.
- *使用PR-73改善了免疫能力强小鼠的感染结果.
结论:
- * 肝素缺乏症是侵入性 * C. albicans * 感染的新型宿主易感性因素.
- * 肝素模仿剂代表了候选血症的潜在治疗策略,特别是在肝病患者中.
相关概念视频
Antimicrobial Proteins
934
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
934
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
Role of Hematopoietic Growth Factors
1.3K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
1.3K
Transmission-based Precautions II: Airborne and Protective Environment
1.2K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.2K
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
356
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
356


