Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Effect of Polymer Concentration and Surface Charge on Controllable Nanopesticides Delivery.

Polymers·2026
Same author

Engineered hierarchical 3D scaffold promotes bone regeneration through enhanced mechanotransduction.

Regenerative biomaterials·2026
Same author

Machine-Learning-Based Prediction of Clinical Outcomes in Gliomas Using Glycomic Features.

Computational and structural biotechnology journal·2026
Same author

Sequential H<sub>2</sub>S-Triggered Redox Relay Nanoprobes for Self-Sustained Chem-Illuminating Cascade Photodynamic Therapy.

Angewandte Chemie (International ed. in English)·2026
Same author

Single-cell analysis revealed potential mechanisms of biomarkers related to polyamine metabolism in osteoarthritis.

Biochemical and biophysical research communications·2026
Same author

Hyperglycosylation is a metabolic driver of Alzheimer's disease.

Nature metabolism·2026

相关实验视频

Updated: Jun 7, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.2K

一个贝叶斯框架,用于全基因组循环节律生物标志物检测.

Haocheng Ding, Lingsong Meng, Yutao Zhang

    bioRxiv : the preprint server for biology
    |November 18, 2024
    PubMed
    概括

    这项研究引入了BayesCircRhy,这是一个新的贝叶斯框架,用于检测全基因组的昼夜节律. 它准确地识别了昼夜基因,改进了分析复杂生物数据的现有方法.

    科学领域:

    • 基因组学就是基因组学.
    • 时间生物学 时间生物学
    • 统计生物信息学是统计的.

    背景情况:

    • 循环节律由基因反循环控制,影响健康.
    • Omics数据分析需要精确的方法来检测昼夜生物标志物.

    研究的目的:

    • 开发一个新的贝叶斯框架,用于全基因组的昼夜节律检测.
    • 结合先前的生物知识和多重测试的控制.

    主要方法:

    • 使用贝叶斯的层次模型.
    • 雇员反跳马尔科夫链蒙特卡洛 (rjMCMC) 用于模型选择.
    • 开发了贝叶斯CircRhy方法和R包"贝叶斯Circadian".

    主要成果:

    • BayesCircRhy展示了优越的虚假发现率控制和稳定性.
    • 该方法在模拟中表现优于现有的方法.
    • 在人类和小鼠RNA-Seq数据中成功识别出已知和新型的昼夜基因.

    结论:

    • 新的贝叶斯框架提供了准确的全基因组检测昼夜节律.
    • BayesCircRhy为昼夜基因识别提供了更好的性能和可靠性.

    更多相关视频

    Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
    10:38

    Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

    Published on: September 27, 2012

    22.3K
    In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
    11:56

    In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

    Published on: September 28, 2017

    9.7K

    相关实验视频

    Last Updated: Jun 7, 2025

    Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
    06:53

    Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

    Published on: November 11, 2016

    8.2K
    Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
    10:38

    Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

    Published on: September 27, 2012

    22.3K
    In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
    11:56

    In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

    Published on: September 28, 2017

    9.7K
  • 公开可用的R包有助于在时代生物学研究中得到更广泛的应用.