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Updated: Jun 7, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

一个贝叶斯框架,用于全基因组循环节律生物标志物检测

Haocheng Ding, Lingsong Meng, Yutao Zhang

bioRxiv : the preprint server for biology

|November 18, 2024

概括

这项研究引入了BayesCircRhy,这是一个新的贝叶斯框架,用于检测全基因组的昼夜节律. 它准确地识别了昼夜基因,改进了分析复杂生物数据的现有方法.

科学领域:

基因组学就是基因组学.
时间生物学时间生物学
统计生物信息学是统计的.

背景情况:

循环节律由基因反循环控制,影响健康.
Omics数据分析需要精确的方法来检测昼夜生物标志物.

研究的目的:

开发一个新的贝叶斯框架,用于全基因组的昼夜节律检测.
结合先前的生物知识和多重测试的控制.

主要方法:

使用贝叶斯的层次模型.
雇员反跳马尔科夫链蒙特卡洛 (rjMCMC) 用于模型选择.
开发了贝叶斯CircRhy方法和R包"贝叶斯Circadian".

主要成果:

BayesCircRhy展示了优越的虚假发现率控制和稳定性.
该方法在模拟中表现优于现有的方法.
在人类和小鼠RNA-Seq数据中成功识别出已知和新型的昼夜基因.

结论:

新的贝叶斯框架提供了准确的全基因组检测昼夜节律.
BayesCircRhy为昼夜基因识别提供了更好的性能和可靠性.
公开可用的R包有助于在时代生物学研究中得到更广泛的应用.

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Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

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相关概念视频

Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...