相关实验视频

Updated: Jun 7, 2025

Observation and Quantification of Telomere and Repetitive Sequences Using Fluorescence In Situ Hybridization FISH with PNA Probes in Caenorhabditis elegans
10:01

Observation and Quantification of Telomere and Repetitive Sequences Using Fluorescence In Situ Hybridization FISH with PNA Probes in Caenorhabditis elegans

Published on: August 4, 2016

10.3K

TeloSearchLR:一个算法来检测使用长序列阅读的新型端粒重复图案

George Chung, Fabio Piano, Kristin C Gunsalus

    bioRxiv : the preprint server for biology
    |November 18, 2024
    PubMed
    概括

    在长DNA测序读取中,TeloSearchLR识别了新的端粒重复动机 (TRMs),克服了短读取工具的局限性. 这种方法有助于发现新的TRM和定基因组组合.

    更多相关视频

    Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization11:29

    Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization

    Published on: July 10, 2017

    12.8K
    Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay08:23

    Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay

    Published on: April 21, 2023

    2.8K

    相关概念视频

    Telomeres and Telomerase02:41

    Telomeres and Telomerase

    In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
    23.1K
    Replication in Eukaryotes02:31

    Replication in Eukaryotes

    Overview
    170.3K
    Next-generation Sequencing03:00

    Next-generation Sequencing

    The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
    Next-Generation Sequencing Methods
    Although all next-generation methods use different technologies, they all share a set of standard features....
    87.6K
    RNA-seq03:21

    RNA-seq

    RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
    Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
    9.8K
    Sanger Sequencing01:57

    Sanger Sequencing

    DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
    753.0K