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Updated: Jun 7, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Published on: August 4, 2019

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用一种突变特异性小分子激活p53Y220C

Xijun Zhu1,2, Woong Sub Byun3,2, Dominika Ewa Pieńkowska4

  • 1Department of Chemistry, Stanford University, Stanford, CA, USA.

bioRxiv : the preprint server for biology
|November 18, 2024
PubMed
概括

研究人员开发了TRanscriptional Activator of p53 (TRAP-1),这是一种新型化合物,可以重新激活突变的瘤抑制蛋白p53. TRAP-1激活突变p53,恢复其瘤抑制功能并抑制癌细胞生长.

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