阿迪波涅丁信号调节尿膀功能,通过使光滑肌肉变得,从而抑制尿素活性的收缩性
bioRxiv : the preprint server for biology
|November 18, 2024
概括
皮菌素 (ADPN) 信号影响膀功能. 在小鼠中,ADPN缺乏导致下泌尿道症状 (LUTS),这表明与肥胖相关的膀功能障碍的新途径.
科学领域:
- 内分泌学 在内分泌学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 代谢综合征研究 代谢综合征研究
背景情况:
- 下尿道症状 (LUTS) 影响超过50%的40岁以上的人,与肥胖和代谢综合征有关.
- 脂肪组织释放adipokines,如adiponectin (ADPN),调节新陈代谢和炎症,但它们在LUTS中的作用尚不清楚.
研究的目的:
- 调查阿迪波涅丁 (ADPN) 在调节膀功能中的作用及其在与代谢功能障碍相关的LUTS中的潜在参与.
主要方法:
- 使用全球ADPN淘汰赛小鼠模型 (Adpn-/-) 来评估膀功能.
- 检查了排泄模式,膀光滑肌肉 (BSM) 收缩性和分子通路.
- 服用ADPN受体激动剂 (AdipoRon) 和AMPK调节剂,以评估它们对BSM收缩的影响.
主要成果:
- Adpn-/-小鼠的排尿频率增加,空腔体积减少,BSM收缩性降低,尤其是缺乏纯能收缩.
- 分子分析显示Adpn-/-小鼠的代谢和纯能信号通路发生了显著的变化.
- 阿迪波隆治疗消除了急性BSM收缩,AMPK激活剂和抑制剂也抑制了BSM纯能收缩.
结论:
- 一个新的ADPN信号通路对于调节BSM收缩性至关重要.
- 这种ADPN通路的失调可能是肥胖和代谢综合征中LUTS的关键机制.
更多相关视频
06:36A Decentralized Ex Vivo Murine Bladder Model with the Detrusor Muscle Removed for Direct Access to the Suburothelium during Bladder Filling
Published on: November 28, 2019
7.1K
06:01Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction
Published on: October 6, 2022
1.5K
相关概念视频
Adrenergic Receptors: ɑ Subtype
1.4K
Adrenoceptors are classified into α and ꞵ classes based on their potencies to catecholamine agonists. α-adrenoceptors show the following order of catecholamine potency:
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
1.4K
Adrenergic Receptors: β Subtype
1.5K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
1.5K
Nitric Oxide Signaling Pathway
4.9K
Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...
4.9K
Endocrine Signaling
64.0K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
64.0K
Parasympathetic Signaling
1.8K
Parasympathetic signaling plays a crucial role in regulating various physiological processes. It involves the release of acetylcholine (ACh) by parasympathetic neurons, which can have localized and short-lived effects. The majority of ACh released is rapidly inactivated at the synapse by the enzyme acetylcholinesterase (AChE), which hydrolyzes Ach into choline and acetate. Additionally, the tissue cholinesterase deactivates any ACh diffusing into the surrounding tissues.
The effects of...
The effects of...
1.8K
Adrenergic Receptors (Adrenoceptors): Classification
2.3K
Adrenergic receptors, or adrenoceptors, respond to the autonomic neurotransmitter noradrenaline and other endogenous catecholamine agonists. They are classified into two main families, α and β, based on their pharmacological response and are further subdivided depending on their location, elicited response, and affinity to specific agonists or antagonists.
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors,...
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors,...
2.3K
