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Updated: May 29, 2026

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

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线粒体NADK2-依赖的NADPH控制人类神经元中Tau寡合体的吸收

Evelyn Pardo, Taylor Kim, Horst Wallrabe

    bioRxiv : the preprint server for biology
    |November 18, 2024
    PubMed
    概括

    线粒体NADK2-依赖的NADPH合成驱动神经元中的陶寡合体 (TauO) 内化,产生与衰老和神经退行性疾病 (如阿尔茨海默氏症) 相关的毒性循环.

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    Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

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    Translocation of Proteins into the Mitochondria01:19

    Translocation of Proteins into the Mitochondria

    Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
    Sorting of outer membrane proteins:
    Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...