KSDKG:基于生物医学文献和公共数据库的结石疾病知识图的构建和应用
Jianping Man1, Yufei Shi1, Zhensheng Hu1
1Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, 510080 China.
Health information science and systems
|November 18, 2024
概括
一个新的结石疾病知识图 (KSDKG) 整合了大量的医疗数据,揭示了隐藏的关联,以帮助研究人员和临床医生了解结石疾病机制.
科学领域:
- 医疗信息学 医疗信息学
- 生物医学知识代表 生物医学知识代表
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 石病 (KSD) 是一种普遍存在的泌尿病状况,全球发病率正在上升.
- 现有的KSD知识在众多数据库中分散,阻碍了全面的理解和研究.
- 对KSD复杂的层次结构和相互连接的有效可视化和表示仍然是一个挑战.
研究的目的:
- 为结石病 (KSD) 构建一个专门的知识图.
- 为了提高医疗专业人员的知识利用.
- 促进KSD的先进临床研究和发现.
主要方法:
- 从PubMed中挖掘KSD相关文章的文献,使用文本解析和语义分析.
- 概念注释与生物医学本体学生成RDF格式的语义数据.
- 整合公共数据库 (UMLS,SNOMED CT,MeSH,药物银行,微生物疾病KG) 用于图形构建.
- 案例研究,以展示KSD知识图的实际应用.
主要成果:
- 开发和实施结石疾病知识图 (KSDKG) 超过9000万的三倍.
- 从29,174篇文章中提取的语义数据,并与多个已建立的生物医学数据库集成.
- 案例研究成功地检索并揭示了与KSD相关的微生物,药物和疾病之间的关联.
- 证明KSDKG能够整合多样化的医学知识,并提供对KSD机制的新见解.
结论:
- KSDKG有效地利用知识图技术来揭示隐藏的知识关联.
- 为KSD相关信息提供增强的语义搜索和响应能力.
- 作为开发其他疾病特定知识图的基础模型,为医学研究做出了重大贡献.
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