甲状腺功能低下与骨质疏松症相关:可能涉及脂质介质
Pengyuan Leng1, Ying Qiu2, Mengxue Zhou2
1Department of Orthopedics, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Frontiers in medicine
|November 18, 2024
概括
这项研究发现,甲状腺功能低下症因果上会增加骨质疏松症的风险. 这种联系可能间接地通过极低密度脂蛋白 (VLDL) 中的甘油三水平来调解.
科学领域:
- 内分泌学 在内分泌学.
- 代谢性骨疾病 代谢性骨疾病
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明甲状腺功能障碍和骨质疏松症 (OP) 之间存在联系.
- 甲状腺疾病和OP之间的因果关系需要进一步阐明.
- 甲状腺激素在骨代谢中起着至关重要的作用.
研究的目的:
- 用孟德尔随机化研究甲状腺功能障碍对骨质疏松风险的因果关系.
- 探索循环代谢物在甲状腺功能低下症-骨质疏松症关联中的潜在调解作用.
- 区分甲状腺功能低下症,甲状腺功能增强症和OP之间的因果关系.
主要方法:
- 使用全基因组关联研究 (GWAS) 数据进行双样本孟德尔随机化 (MR) 分析.
- 逆方差加权 (IVW) 模型和多变量MR (MVMR) 用于因果推断.
- 通过MR-PRESSO和留出一个的分析来评估型和异质性.
- 调解分析包括249种循环中的代谢物.
主要成果:
- 甲状腺功能低下症 (OR=1.092) 和甲状腺功能过高症 (OR=1.080) 显示与增加的OP风险存在因果关系.
- 多变量MR证实甲状腺功能低下症 (OR=1.082) 是OP的持续风险因素.
- 调解分析表明,大VLDL中的甘油三可能调解2.47%的甲状腺功能低下-OP效应.
结论:
- 甲状腺功能低下症与骨质疏松症的风险增加有关.
- 甲状腺功能低下症和OP之间的关联可能部分由大VLDL中的甘油三水平介导.
- 需要进一步的研究才能充分理解直接和间接的因果关系.
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