改进了交叉快速扫描周期电压测量和电生理学测量的电路和后处理
Ashwin K Avula1, Abhinav Goyal2,3,4, Aaron E Rusheen2,3,4
1Division of Engineering, Mayo Clinic, Rochester, MN, United States.
Frontiers in signal processing
|November 18, 2024
概括
这项研究引入了一种新的方法来减少大脑记录中的文物,使神经活动和神经化学释放的分析更快,更准确. 新技术显著提高了数据采集的速度和完整性.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 信号处理 信号处理
背景情况:
- 使用碳纤维微电极 (CFMs) 结合电生理学和电化学,可以对神经活动和神经化学释放进行广泛的分析.
- 在这些系统中使用的模拟CMOS交换机引入充电注入器件,延迟信号恢复并减弱重要的低频局域潜力 (LFP) 数据.
研究的目的:
- 开发一种方法,以克服电荷注入器件在交联的电生理学和电化学记录中.
- 为了保护有价值的低频LFP频段,同时提高信号恢复速度.
主要方法:
- 在CMOS开关之前集成了一个电压追随器操作放大器,以增加电流流量并消散注入的电荷.
- 在后处理中实施单项指数建模,以表征和减去剩余的短暂电压工件.
主要成果:
- 通过硬件添加,实现了电生理学获取延迟的16.98%降低.
- 将电生理学数据恢复时间缩短到3.26 ± 0.22 ms,比以前的方法改进了60%.
- 尽量减少LFP信号的衰减,保持网络层面的洞察力.
结论:
- 拟议的硬件和软件解决方案有效地减轻了电力生理学和电化学记录中的充电注入器件.
- 这一进步使得联合测量的扫描速率更高,提高了神经活动和神经化学释放的综合分析.
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