中枢神经系统癌症后对生育能力的长期影响:系统性审查和元分析
Janna Pape1, Tanya Gudzheva1, Danijela Beeler1
1Division of Gynecological Endocrinology and Reproductive Medicine, University Women´s Hospital, Inselspital Bern, University of Bern, Bern, Switzerland.
Neuro-oncology practice
|November 18, 2024
概括
中枢神经系统 (CNS) 癌症幸存者面临生育问题. 这项审查发现20%的经历性腺毒性,但75%的受孕能力被保留,突出了需要受孕能力保护咨询的需要.
科学领域:
- 在瘤学瘤学.
- 生殖医学 生殖医学
- 系统审查是系统的审查.
背景情况:
- 中枢神经系统 (CNS) 癌症在年轻人中普遍存在.
- 由于治疗的进步,中枢神经系统癌症的幸存者越来越多地面临生育挑战.
- 目前的指导方针建议在发生性腺毒性治疗之前进行生育咨询,但性腺毒性需要进一步审查.
研究的目的:
- 系统地审查中枢神经系统癌症患者的淋巴腺毒性和生育能力的保护.
- 分析中枢神经系统癌症治疗后淋巴腺毒性和保存生育能力的流行情况.
- 为中枢神经系统癌症幸存者提供生育咨询的基础.
主要方法:
- 在MEDLINE,Embase和Cochrane数据库中进行系统的文献搜索.
- 包括治疗中枢神经系统恶性癌症的患者的研究.
- 遵守系统审查和元分析 (PRISMA) 准则的首选报告项目.
主要成果:
- 分析了31项涉及4590名患者的研究.
- 淋巴腺毒性的综合流行率为20% (95% CI: 10%-34%).
- 在75% (95% CI: 64%-83%) 的患者中观察到保存的生育能力,长期维持.
结论:
- 该元分析为中枢神经系统癌症治疗后的生育咨询提供了见解.
- 高异质性和缺乏个体患者数据限制了精确的生育预后.
- 对于中枢神经系统癌症患者,仍然强烈建议采取生育能力保护措施.
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