重离子空间辐射对囊细胞亚群和NK细胞毒性功能的晚期影响
Calvin N Leung1, Donna M Howell1,2, Sonia M de Toledo1
1Department of Radiology, New Jersey Medical School, Rutgers University, Newark, NJ, USA.
概括
高能离子暴露会在几年后损害自然杀手 (NK) 细胞的功能. 这项研究表明,分离的HZE粒子暴露会降低NK细胞活动,影响深空任务上的宇航员的免疫健康.
科学领域:
- 太空探索 太空探索
- 辐射生物学 辐射生物学
- 免疫学 免疫学 免疫学
背景情况:
- 增加太空探索需要了解长期的健康风险.
- 高原子数,高能量 (HZE) 离子暴露对免疫系统的影响,特别是晚期影响,尚不清楚.
- 在中年暴露于HZE粒子的老年小鼠中,研究了自然杀手 (NK) 细胞种群,以模拟老年宇航员.
研究的目的:
- 确定HZE离子暴露对NK细胞种群和小鼠功能的长期影响.
- 评估不同的HZE离子和分成方案如何影响NK细胞细胞毒性.
- 为执行长期航天任务的宇航员提供有关潜在免疫系统风险的见解.
主要方法:
- 小鼠在不同的剂量和分成方案中暴露于马射线或各种HZE离子 (Si,O).
- 测量NK细胞细胞毒性是通过与标记的细胞与标记的细胞共同培养.
- 流细胞计用于确定脏细胞群中的NK,B和T淋巴细胞的百分比.
主要成果:
- 分割式16O8+离子暴露 (40cGy,3分) 和150-cGy马射线显著降低NK细胞细胞毒性约25%和30%,分别在暴露后1-1.5年.
- 单分数16O8+离子暴露 (40cGy,1分) 和Si14+离子暴露 (40cGy,3分) 并没有显著改变NK细胞细胞毒性.
- 在脏细胞群体内NK细胞的百分比没有显著的差异.
结论:
- 对HZE离子的分离暴露可能导致长期减少NK细胞功能,这是先天免疫系统的关键组成部分.
- 这些发现表明,由于太空辐射暴露,宇航员的免疫健康存在潜在风险.
- 开发保护性对策可能是必要的,以减轻宇航员长期免疫功能下降的风险.
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