已知或疑似阻塞性睡眠呼吸暂停的性别特异性痴呆风险:一项为期10年的基于人口的纵向研究
Tiffany J Braley1,2, Xiru Lyu3, Galit Levi Dunietz1
1Division of Sleep Medicine, Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
Sleep advances : a journal of the Sleep Research Society
|November 18, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 会增加老年人的痴呆风险,尤其是女性. 这项研究强调OSA是痴呆症发展的重要,可修改的因素.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是老年人中普遍存在的疾病.
- 需要进一步调查OSA和痴呆风险之间的关联,特别是关于性别特异性的差异.
- 了解痴呆症的可修改风险因素对于公共卫生至关重要.
研究的目的:
- 调查已知或疑似阻塞性睡眠呼吸暂停 (OSA) 与老年人10年内发展痴呆症的风险之间的性别特异关系.
- 量化与OSA相关的痴呆症在50岁及以上的女性和男性的累积发病率.
主要方法:
- 来自健康和退休研究 (HRS) 的18815名没有痴呆症的参与者 (50岁以上) 的分析.
- 阻塞性睡眠呼吸暂停 (OSA) 状态由自我报告或验证的查工具项目 (STOP-Bang) 确定.
- 使用经过验证的基于HRS的算法识别的事件痴呆病例;使用调查加权回归模型估计的性别和年龄特定差异.
主要成果:
- 已知/怀疑的OSA在男性 (68%) 比女性 (31%) 更常见.
- 在80岁时,OSA与男女痴呆症的累积发病率较高有关 (女性高4.7%,男性高2.5%).
- 在OSA和痴呆风险之间调整后的关联减弱了,但在男女中仍然具有统计学意义.
结论:
- 阻塞性睡眠呼吸暂停 (OSA) 是老年人痴呆风险的重要因素,对女性有明显的影响.
- 这项研究强调了OSA作为痴呆症发病的潜在可修改的风险因素.
- 在老年人群中对OSA进行进一步的研究和临床关注可能有助于减轻痴呆风险.
更多相关视频
04:53Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
Published on: October 18, 2024
705
06:23A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
Published on: September 22, 2020
5.3K
相关概念视频
Sleep Apnea
129
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
129
Insufficient Sleep and Sleep Deprivation
134
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
134
Dementia
97
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
97
Other Pulmonary Disorders
804
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
804
Sleepwalking and Sleep Talking
122
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
122
Alzheimer's Disease: Overview
448
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
448
