综合的多omics分析突出了低热量饮食中的饮食-肠-大脑轴,促进了寻求新奇的行为
Shuangping Wang1, Ling-Yan Su1,2, Junquan Chen1
1College of Food Science and Technology, Yunnan Agricultural University, No. 452 Fengyuan Road, Kunming, 650000, China.
Current research in food science
|November 18, 2024
概括
低热量 (LC) 饮食通过改变肠道微生物群和增加大脑中的Areg基因表达,增强了小鼠的探索行为. 这表明饮食,肠道健康和认知功能之间存在联系.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 遗传学 是一个遗传学.
背景情况:
- 饮食显著影响神经生理学,影响情绪,认知和心理健康.
- 饮食模式影响大脑功能和情绪的确切机制在很大程度上仍未被探索.
研究的目的:
- 为了研究各种饮食模式对小鼠行为的影响.
- 探索饮食引起的大脑功能和行为的变化背后的分子机制.
主要方法:
- 给小鼠食不同的饮食,包括低热量 (LC) 饮食.
- 用宿主转录组测序和元基因组测序来分析基因表达和肠道微生物群组成.
- 在体内小鼠表型化 (IMPC) 用于评估行为变化,特别是对新环境的探索.
主要成果:
- 食LC的小鼠表现出对新鲜食物,物体和环境的探索行为增加.
- 食LC导致Areg基因在大脑皮层的表达增加.
- 在LC食小鼠中观察到特定肠道细菌 (s_Schaedlerella和s_1XD8-76) 的显著增加.
- 综合分析显示68种不同的代谢物与LC食小鼠的Areg上调相关.
结论:
- 低热量饮食可以恢复肠道微生物群的平衡,并增强寻求新奇的行为.
- 与微生物群相关的代谢物可以调节宿主基因转录,将饮食模式与大脑功能联系起来.
- 这项研究提供了通过肠-大脑轴调节对饮食对大脑情感和认知中心的影响的证据.
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