外源性的使用与初级前十字带断裂风险之间的关系
Matthew Quinn1, Alex Albright1, Nicholas J Lemme1
1Department of Orthopaedic Surgery, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Orthopaedic journal of sports medicine
|November 18, 2024
概括
替代疗法 (TRT) 与前十字带 (ACL) 撕裂的风险更高有关. 然而,在本研究中,TRT并没有增加ACL重建失败的风险.
科学领域:
- 整形外科 整形外科 整形外科
- 内分泌学 在内分泌学.
- 运动医学 运动医学
背景情况:
- 替代疗法 (TRT) 的使用在美国显著增加.
- 在接受TRT的患者中,关于带损伤,特别是前十字带 (ACL) 撕裂的风险的证据有限.
研究的目的:
- 为了调查TRT和ACL损伤的发生率之间的联系.
- 评估在TRT患者中ACL重建 (ACLR) 失败的后续风险.
- 为了确定TRT是否会增加一次性ACL损伤和ACL复发的风险.
主要方法:
- 使用PearlDiver数据库 (2011-2020) 的回顾性队列研究.
- 包括年龄在18-59岁之间的患者,他们填写了丸激素处方,与没有使用丸激素的对照组相匹配.
- 分析国际疾病分类 (ICD) 和当前程序术语 (CPT) 代码,以识别ACL损伤和重建.
- 多变量后勤回归用于比较6个月,1年和2年的ACL损伤率,以及最长5年的ACLR故障率.
主要成果:
- 这项研究包括851,816名患者 (425,908名TRT组).
- 接受TRT的患者在6个月 (OR,2.66),1年 (OR,2.46) 和2年 (OR,2.22) 经历ACL撕裂的可能性显著更高.
- 在手术后5年内,TRT和对照组之间没有观察到在ACL重建失败率上有统计学意义的差异.
结论:
- 接受替代疗法的个人有显著增加维持初级ACL破裂的风险.
- 替代疗法似乎不会增加ACL重建后失败的风险.
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