用gasdermin E武装瘤性M1病毒可以增强乳腺癌的抗瘤疗效
Xiao-Yu Chen1, Ying Liu2, Wen-Bo Zhu1
1Departments of Pharmacology, Sun Yat-sen University, No. 074, Zhongshan Second Road, Guangzhou 510080, China.
iScience
|November 18, 2024
概括
工程化瘤病毒输送气皮素E (GSDME) 诱导热,增强癌细胞死亡和抗瘤免疫力. 这种新的方法为广泛的转移性乳腺癌病变提供了有希望的全身疗法.
科学领域:
- 瘤治疗性病毒疗法
- 免疫治疗是一种免疫疗法.
- 癌症生物学 癌症生物学
背景情况:
- 激素灭绝,一个被编程的细胞死亡途径,是由gasdermin蛋白 (GSDM) 触发的,并通过招募淋巴细胞到瘤微环境 (TME) 来增强抗瘤免疫力.
- 由于局部应用,目前诱导热的疗法在治疗广泛或微观转移性病变方面存在局限性.
研究的目的:
- 为了设计瘤性M1病毒,选择性地将气皮素E (GSDME) 传递给瘤细胞,诱导灭.
- 在乳腺癌模型中评估表达GSDME的型病毒的疗效.
主要方法:
- 开发用于表达GSDME的瘤性M1病毒 (rM1-mGSDME_FL和rM1-mGSDME_NT).
- 在乳腺癌模型中对改性病毒进行体外和体内测试.
- 评估瘤细胞死亡,瘤生长抑制,存活率和免疫细胞透.
主要成果:
- 在乳腺癌模型中,修改后的病毒显著增强了瘤细胞死亡.
- 在小鼠中,抗瘤病毒治疗抑制了瘤生长并延长了生存时间.
- 通过病毒诱导GSDME介导的烧会促进免疫细胞透到瘤中.
结论:
- 工程化解性M1病毒有效诱导热,并表现出显著的抗癌潜力.
- 这种病毒传递系统为转移性乳腺癌的全身治疗提供了一个有希望的策略.
更多相关视频
07:13Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer
Published on: March 26, 2014
23.3K
07:20Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation
Published on: January 14, 2011
14.7K
相关概念视频
01:27Tumor Immunotherapy
480
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
480
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
02:38Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K