Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

592
Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
592

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Risk factors for atrial fibrillation in Ibadan, Nigeria: A case-controlled study.

Journal of the National Medical Association·2026
Same author

Prevalence and inequalities of missed opportunities for intermittent preventive therapy (IPTp) of malaria among pregnant women: an analysis of 2018 Nigeria DHS.

Malaria journal·2026
Same author

Educational attainment is associated with reduced functional decline in Puerto Ricans with elevated pTau181.

Journal of Alzheimer's disease : JAD·2026
Same author

Community voices: Exploring beliefs, attitudes, practices and recommendations for improving stroke prevention and stroke care in rural and urban communities in Nigeria.

PloS one·2026
Same author

Clinical Manifestations.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Biomarkers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

相关实验视频

Updated: Jun 7, 2025

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
09:52

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

9.3K

预测模型用于aminoglycoside诱导的耳毒性.

Adebolajo A Adeyemo1,2, Josephine Adeolu1, Joshua O Akinyemi3

  • 1Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Frontiers in neurology
|November 18, 2024
PubMed
概括

氨基糖化物耳毒性,一个显著的听力损失的风险,现在可以预测在一般人群. 一个新的模型将年龄,累积剂量和基线听力确定为关键预测因素,改善临床护理.

关键词:
氨基甘油酸氨基化物.模型验证模型验证耳毒性 耳毒性 耳毒性预测模型是一个预测模型.结核病是一种肺结核病.

更多相关视频

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
12:21

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

Published on: November 26, 2015

17.3K
Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
09:06

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Published on: January 9, 2019

13.8K

相关实验视频

Last Updated: Jun 7, 2025

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
09:52

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Published on: March 16, 2018

9.3K
The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
12:21

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration

Published on: November 26, 2015

17.3K
Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
09:06

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Published on: January 9, 2019

13.8K

科学领域:

  • 药理学和毒理学 药理学和毒理学
  • 耳鼻喉科 耳鼻喉科 耳鼻喉科
  • 生物统计学 生物统计学

背景情况:

  • 氨基甘油酸抗生素与不可逆转的听力损失有关,这是一个关键的不良影响.
  • 准确预测氨基糖化物诱导的耳毒性仍然是一个重大的临床挑战.
  • 这项研究的目的是开发适用于一般人群的氨基糖化物耳毒性预测模型.

研究的目的:

  • 开发和验证氨基糖化物耳毒性预测模型.
  • 确定在接受基于斯特雷普托米辛的抗结核治疗的患者中对耳毒性的关键临床和听力学预测因素.

主要方法:

  • 研究了一组潜在的153名成年人,他们接受了针对非耐药结核病的斯特雷普托米辛治疗.
  • 定期进行高频纯色音量计,以评估听力变化.
  • 使用后勤回归来开发一个包含年龄,累积剂量和基线纯色调平均值 (PTA) 等变量的预测模型.

主要成果:

  • 在35%的参与者中观察到耳毒性.
  • 年龄,累计斯特雷普托米辛剂量和基线PTA被确定为耳毒性显著预测因素.
  • 开发的模型表现出良好的区分能力,接收器运行特征曲线下的面积为0.84的培训和0.79的验证.

结论:

  • 已经开发出了一种经过验证的aminoglycoside耳毒性预测模型.
  • 该模型利用年龄,累积剂量和基线PTA,可以帮助预测一般人群中耳毒性风险.
  • 这些发现可以改善临床管理和有关氨基糖类药物治疗的患者咨询.