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相关概念视频

Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
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Structure of Cadherins01:25

Structure of Cadherins

3.3K
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
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Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
6.6K
Anchoring Junctions01:03

Anchoring Junctions

3.6K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
3.6K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
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Catenins01:23

Catenins

2.3K
Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
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相关实验视频

Updated: Jun 7, 2025

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
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CEACAM1互动的结构方面

Amit K Gandhi1, Yu-Hwa Huang1, Zhen-Yu J Sun2

  • 1Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

European journal of clinical investigation
|November 18, 2024
PubMed
概括

癌胚抗原相关细胞粘附分子1 (CEACAM1) 是一个关键的细胞粘附分子,参与免疫反应和疾病. 本审查详细介绍了CEACAM1的情况.

关键词:
在CEACAM1中.粘附性 粘附性 粘附性 粘附性主机的功能是主机的功能.免疫功能 免疫功能 免疫功能

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The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy
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Lipid Vesicle-mediated Affinity Chromatography using Magnetic Activated Cell Sorting LIMACS: a Novel Method to Analyze Protein-lipid Interaction
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相关实验视频

Last Updated: Jun 7, 2025

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

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The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy
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The C. elegans Intestine As a Model for Intercellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis at the Single-cell Level: Labeling by Antibody Staining, RNAi Loss-of-function Analy

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Lipid Vesicle-mediated Affinity Chromatography using Magnetic Activated Cell Sorting LIMACS: a Novel Method to Analyze Protein-lipid Interaction
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Lipid Vesicle-mediated Affinity Chromatography using Magnetic Activated Cell Sorting LIMACS: a Novel Method to Analyze Protein-lipid Interaction

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科学领域:

  • 免疫学和细胞生物学
  • 分子相互作用和信号传输

背景情况:

  • 癌胚抗原相关细胞粘附分子1 (CEACAM1) 是一种具有多种免疫和非免疫功能的关键膜蛋白.
  • CEACAM1作为同型和异型连接体,与CEACAM5,TIM-3和PD-1等蛋白质相互作用.
  • 病原体利用CEACAM1进行宿主入侵和免疫逃避,突出其在传染病,自身免疫和癌症中的临床相关性.

研究的目的:

  • 审查CEACAM1同型和异型连接体相互作用的结构基础.
  • 讨论CEACAM1在cis和trans结合中的单,二和寡状态的调节.
  • 探索下游信号的影响和贪在CEACAM1活动中的作用.

主要方法:

  • 文献综述侧重于CEACAM1.1的结构生物学和分子相互作用.
  • 分析CEACAM1的调控机制,包括cis/trans结合和寡合化.
  • 探索CEACAM1在各种生物环境中的功能后果.

主要成果:

  • 详细的结构洞察CEACAM1的带结合能力.
  • 了解CEACAM1的结构状态如何影响下游信号的理解.
  • 确定贪作为CEACAM1功能的潜在调节器.

结论:

  • CEACAM1的多方面的相互作用和监管状态对于其多样化的生物作用至关重要.
  • 了解CEACAM1的结构功能关系是它对疾病的影响的关键.
  • 对CEACAM1狂热的进一步研究可能会揭示新的治疗策略.