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Updated: Jul 2, 2026

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校正:二氧化纳米颗粒的生物活性作为尺寸和表面特征的函数

Veronika Sarnatskaya1, Yuliia Shlapa2, Denis Kolesnik1

  • 1R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of the NAS of Ukraine, 45, Vasylkivska Str., Kyiv, 03022, Ukraine. vsnikavera@gmail.com.

Biomaterials science
|November 18, 2024
PubMed
概括

此修正澄清了二氧化纳米粒子尺寸和表面特征对其生物活性的影响. 了解这些特性对于开发有效的纳米材料用于生物医学应用至关重要.

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...