Brassica rapa L.原始多糖化合物中和共生发酵乳清饮料改善了催性低氧诱导的肠道损伤
Yuanlin Niu1,2, Tingting Zhao1,2, Zhenjiang Liu2,3
1School of Public Health, Lanzhou University, Lanzhou, China. huangxiaodan@lzu.edu.cn.
Food & function
|November 18, 2024
概括
一种新的协生性发酵乳清饮料,结合了和Brassica rapa多糖,可以防止高海拔损伤. 它减少了氧化应激和炎症,改善了肠道健康,并增强了小鼠的有益肠道细菌.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 高海拔地区的生理学
背景情况:
- 低压性缺氧会诱导氧化应激,炎症和肠道疾病.
- 由于氧气供应减少,高海拔环境对健康构成重大挑战.
- 开发有效的营养对抗措施对缺氧引起的损伤至关重要.
研究的目的:
- 开发和评估一种协生性发酵乳清饮料,以检测其对小鼠的抗低性缺氧诱导损伤的保护作用.
- 研究饮料对氧化应激,肠道屏障功能和肠道微生物群的影响.
- 探索潜在的分子机制,包括代谢和信号通路调节.
主要方法:
- 开发一种共生发酵乳清饮料,使用开和Brassica rapa L.原始多糖.
- 建立一个催眠性缺氧小鼠模型来模拟高海拔条件.
- 评估肠道完整性,氧化应激标志物,肠道微生物群组成,短链脂肪酸 (SCFA) 生产和关键信号通路 (例如AMPK).
主要成果:
- 协生发酵乳清饮料表现出强大的发酵和抗氧化特性.
- 它显著降低了氧化应激,保护了肠道结构,减少了炎症,并在暴露于缺氧的小鼠中降低了亡.
- 饮料调节了肠道微生物群,丰富了有益的细菌 (例如,肠道菌),减少了有害的细菌 (例如,Marvinbryantia),增加了SCFA的产生,并增加了柏柏林和尼古丁酸水平,激活了AMPK通路.
结论:
- 协生发酵乳清饮料有效地缓解了小鼠的催性低氧诱导的肠损伤.
- 它的保护作用通过减少氧化应激,加强肠道屏障,调节肠道微生物群和相关代谢物来调节.
- 这项研究表明,协生菌和乳清发酵作为高海拔环境的新营养干预措施的潜力.
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