目前的吸烟与系统性红斑狼患者的严重损伤有关
M A Cosatti1, S A Muñoz2, M T Tamborenea3
1Centro de Educación Médica e Investigaciones Clínicas, CEMIC "Norberto Quirno", Buenos Aires, Argentina.
Lupus
|November 18, 2024
概括
目前的吸烟与系统性红斑狼 (SLE) 患者的严重器官损伤有关. 这项研究强调吸烟是增加系统性狼国际合作诊所/美国风湿病学学院SLE评分损害指数的可修改风险因素.
科学领域:
- 类风湿病学 类风湿病学
- 临床免疫学临床免疫学
- 流行病学 流行病学
背景情况:
- 系统性红斑狼 (SLE) 是一种具有显著发病率的慢性自身免疫性疾病.
- 器官损伤累积是SLE患者长期结果的关键决定因素.
- 吸烟等生活方式因素对SLE进展的影响需要进一步调查.
研究的目的:
- 评估阿根廷SLE患者队列中吸烟状态和器官损伤之间的关联.
- 使用系统性狼国际合作诊所/美国风湿病学学院SLE损伤指数 (SLICC-SDI) 来量化器官损伤.
- 确定导致SLE中严重器官损伤 (SLICC-SDI ≥3) 的危险因素.
主要方法:
- 一项横截面研究包括623名连续SLE患者,符合1997年ACR标准.
- 收集的数据包括社会人口统计学变量,疾病特征,吸烟状况和SLICC-SDI得分.
- 患者被分为当前吸烟者或非吸烟者 (从未吸烟或曾吸烟者);严重损伤被定义为SLICC-SDI≥3.3.
主要成果:
- 当前吸烟与严重器官损伤的风险增加有关 (SLICC-SDI≥3) (OR1.82,p=0.046).
- 严重损伤的其他显著预测因素包括年龄较大 (OR 1.04,p=0.034),疾病持续时间较长 (OR 1.03,p=0.021) 和循环胺暴露 (OR 2.97,p=0.002).
- 16%的患者是目前的吸烟者,17%的患者SLICC-SDI≥3.
结论:
- 目前的吸烟是SLE队列中严重器官损伤的独立风险因素.
- 老年,疾病持续时间较长以及使用环胺也会导致器官损伤增加.
- 这些发现强调了戒烟在治疗SLE患者中的重要性,以防止长期损伤.
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