相关实验视频

Updated: Jun 7, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

美国肝细胞癌死亡率的趋势和2040年的预测

Sikai Qiu¹, Jiangying Cai², Zhanpeng Yang³

¹Department of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

JAMA network open

|November 18, 2024

概括

肝细胞癌 (HCC) 的死亡率正在上升,由酒精相关的肝病 (ALD) 和代谢功能障碍相关的脂肪性肝病 (MASLD) 推动. 预测显示,到2026年,ALD将成为首要原因,到2032年,MASLD将成为第二大原因.

科学领域:

肝病学和瘤学肝病学和瘤学
公共卫生监督公共卫生监督
流行病学流行病学

背景情况:

肝癌,特别是肝细胞癌 (HCC),对全球健康构成重大负担.
近几十年来,在全球范围内,HCC发病率和死亡率都有明显的增加.

研究的目的:

分析2006年至2022年美国HCC年龄标准化死亡率 (ASMR) 的趋势.
预测HCC的ASMR到2040年.

主要方法:

一项采用国家生命统计系统 (2006-2022) 的数据进行的横截面研究.
分析包括188,280例与HCC相关的死亡,按肝病病因 (ALD,HBV,HCV,MASLD),年龄,性别和种族/民族分层.
结点回归用于趋势分析,Prophet和AutoARIMA模型用于预测.

主要成果:

总体而言,HCC的ASMR在2022年为每10万人的5.03,预计到2040年将达到6.39.
死亡率在ALD和MASLD上升,而在HCV和HBV下降.
预计到2026年,ALD将成为HCC死亡的主要原因,到2032年,MASLD将成为第二大原因.

结论:

该研究强调了HCC死亡率驱动因素的显著转变,其中ALD和MASLD成为主要关注点.
这些发现强调了有针对性的公共卫生干预和风险分层战略的必要性.
及时识别高风险人群对于减轻HCC日益增长的负担至关重要.

更多相关视频

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

Generation of Subcutaneous and Intrahepatic Human Hepatocellular Carcinoma Xenografts in Immunodeficient Mice

Published on: September 25, 2013

相关概念视频

Cancer Survival Analysis

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...