甲状腺恒温参数与对多基基物质和多基基物质暴露之间的关联
Xinwen Yu1, Yufei Liu1, Meiying Wang1
1Department of Endocrinology, The Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, Shaanxi, China.
The Journal of clinical endocrinology and metabolism
|November 18, 2024
概括
和多基物质 (PFAS) 暴露与美国成年人的周围甲状腺激素敏感性变化有关. 这项研究突出了超越单个甲状腺激素的潜在健康影响,重点关注平衡的破坏.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 基和多基物质 (PFAS) 是已知的破坏甲状腺平衡的环境污染物.
- 以前的研究主要集中在单个PFAS对特定甲状腺激素的影响上.
研究的目的:
- 调查暴露于各种PFAS和成人的综合性甲状腺平衡参数之间的关联.
- 为了区分PFAS对中央和外围甲状腺激素敏感性的影响.
主要方法:
- 从NHANES (2007-2008,2011-2012) 对2386名美国成年人的分析.
- 使用甲状腺激素水平计算中部和外围甲状腺激素敏感度.
- 应用多变量回归,加权量子总和 (WQS) 和量子G计算 (QGC) 模型来评估PFAS-甲状腺关系和共同暴露.
主要成果:
- 在特定的PFAS (PFOA,PFOS,PFNA,PFHxS) 和自由三甲状腺素/自由甲状腺素比率 (FT3/FT4) 和外围神酶活性 (SPINA-GD) 之间发现了积极的关联.
- 在PFAS暴露和中央甲状腺敏感度参数之间没有观察到显著的关联.
- WQS和QGC模型证实,混合PFAS的共同暴露与FT3/FT4和SPINA-GD正相关,PFOA是一个重要的贡献者.
结论:
- 在美国一般成年人群中,PFAS暴露似乎影响了外围甲状腺激素敏感性,而不是中心敏感性.
- 这些发现有助于更好地了解有关甲状腺功能的PFAS毒理及其更广泛的健康影响.
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