对于甲状腺激素的敏感性和成人甲状腺腺体内肥的关联
Ying Wei1, Mengge Yang1, Jia Liu1
1Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
The Journal of clinical endocrinology and metabolism
|November 18, 2024
概括
降低中央甲状腺激素 (TH) 敏感性与女性内脏脂肪增加有关,但男性并非如此. 这突显了TH的灵敏度.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 甲状腺激素 (TH) 在调节新陈代谢方面发挥着至关重要的作用.
- 肥胖,特别是内脏脂肪,是严重的公共卫生问题.
- 了解TH敏感性和肥胖之间的关系对于代谢健康管理至关重要.
研究的目的:
- 为了研究中枢甲状腺激素 (TH) 敏感性和肥胖指标 (BMI,VAI) 之间的关联,在成人中.
- 为了探索这种协会中潜在的性别差异.
主要方法:
- 一项涉及10960名甲状腺功能良好的成年人 (5411名男性,5749名女性) 的截面研究.
- 使用甲状腺反量基指数 (TFQI),甲状腺刺激激素指数 (TSHI) 和甲状腺增生性T4抵抗指数 (TT4RI) 评估中央TH敏感性.
- 使用内脏脂肪指数 (VAI) 评估内脏肥胖;用于按性别分层分析的逻辑和线性回归.
主要成果:
- 在男性中,较高的TT4RI与调整后的BMI增加有关 (P=0.001).
- 在男性或女性中,BMI和TH敏感度指数之间没有显著的关联.
- TH敏感度指数与女性的VAI正相关 (ORs在最高与最低三角动物之间从1.21到1.47不等;P<0.05).
- 在男性中,TH敏感度和VAI之间没有显著的关联.
结论:
- 降低中心TH敏感性与女性内脏脂肪增加有关.
- 这些发现表明TH敏感性在代谢障碍的发展中具有性别特异性的作用.
- 强调在管理肥胖症,特别是女性肥胖症时考虑TH敏感性的重要性.
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