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系统性炎症反应指数与肉类症患者的死亡率之间的关联

Yifan Lu^1,2, Chengyin Lu^1,2, Zhiqiang Luo^1,2

¹The Second Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.

|November 18, 2024

概括

系统性炎症反应指数 (SIRI) 与肉类症患者的死亡风险较高有关. 这一发现凸显了SIRI作为该人口死亡率增加的潜在指标.

科学领域:

老年学是指老年学的学科.
炎症研究炎症研究
公共卫生公共卫生

背景情况:

萨科佩尼亚是一种肌肉损失的特征,与炎症有关.
系统性炎症反应指数 (SIRI) 与肉症患者的死亡率之间的关系尚不清楚.

研究的目的:

研究被诊断为肉类的个体中SIRI和死亡风险之间的关联.
为了确定SIRI是否可以作为萨尔科佩尼亚患者死亡率的预测标记.

主要方法:

从1999-2018年全国健康和营养检查调查 (NHANES) 的十个周期中分析了3,141名肉类患者的数据.
死亡率数据从国家死亡指数收集到2019年12月31日.
考克斯比例危险模型和平滑曲线拟合被用于评估SIRI水平和死亡率之间的关联,并进行了敏感性和子组分析.

主要成果:

较高的SIRI水平 (SIRI Q3组) 与所有原因死亡率 (HR 1.24) 和心血管疾病死亡率 (HR 1.46) 的风险增加有关.
这种关联在各种人口学子组中仍然显著,包括糖尿病和高血压患者.
敏感性分析证实了研究结果的可靠性,即使在排除了某些高风险群体之后.

结论:

这项研究确立了SIRI升高与20岁及以上的肉症患者死亡风险增加之间的显著联系.
现在,SIRI已经成为一种有价值的生物标志物,用于预测萨科佩尼亚患者的死亡率.

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