塞克雷丁输液降低了健康男性的食物摄入量 - 一项随机,安慰剂控制,双盲,交叉研究
Sebastian M N Heimbürger1,2, Maria J Bentzen1, Hüsün S Kizilkaya1,3
1Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup 2900, Denmark.
European journal of endocrinology
|November 18, 2024
概括
秘激素的使用减少了健康男性的食物摄入量. 这种效应与饭后棕色脂肪组织 (BAT) 活动的增加有关,这表明它可能在食欲调节中发挥作用.
科学领域:
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
- 人体生理学 人体生理学
背景情况:
- 众所周知调节十二指肠pH值的激素秘在小鼠中表现出厌食性质.
- 在小鼠中,这些效应被认为是通过红蛋白诱导的棕色脂肪组织 (BAT) 激活的介导.
- 目前的研究调查了这些影响在人类受试者.
研究的目的:
- 为了研究外源性分泌素对健康男性志愿者的食物摄入的影响.
- 评估分泌素对棕色脂肪组织 (BAT) 活动的影响.
- 为了检查分泌素对食后生理学的影响.
主要方法:
- 一项随机,安慰剂控制,双盲,交叉研究,涉及25名健康男性.
- 参与者在5个小时内接受了静脉注射的秘或安慰剂,并有2个月的洗期.
- 食物摄入量,BAT活动 (通过热成像) 和生理参数在饭后进行评估.
主要成果:
- 与安慰剂相比,secretin显著降低了173千卡路里的ad libitum食物摄入量 (P = .039).
- 机密素急剧下降,但食后增加了BAT活性.
- 秘影响了胆囊体积,胆酸合成和循环中的脂酶,粉酶和甘油三,但不影响胃排空.
结论:
- 在健康的男性中注入秘可以减少随意的食物摄入量.
- 在使用秘后,观察到棕色脂肪组织 (BAT) 活动的食后增加.
- 研究结果表明,秘密素在人类的食欲调节和能量消耗方面起着作用.
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