克服瘤缺氧木基三元异构连接使缺陷调制增强瘤声触媒免疫疗法
Zongyan He1, Qian Wang2, Jun Du2
1Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200030, China; Institute of Bismuth Science, School of Materials and Chemistry, Shanghai Collaborative Innovation Center of Energy Therapy for Tumors, University of Shanghai for Science and Technology, Shanghai, 200093, China.
一种基于石的新型材料 (BBOP) 通过增强反应性氧物种 (ROS) 来增强声触媒疗法,从而触发癌细胞死亡并激活免疫反应,提高抗瘤功效.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 癌症免疫疗法癌症免疫疗法
背景情况:
- 声催化诱导的活性氧物种 (ROS) 可以启动编程细胞死亡 (PANoptosis) 和免疫细胞死亡 (ICD) 癌症免疫疗法.
- 有限的ROS生成和免疫抑制瘤微环境阻碍了当前声免疫疗法的有效性.
研究的目的:
- 开发一种先进的声敏剂,用于增强癌症免疫疗法.
- 通过改进ROS生成和免疫反应激活来克服现有的声免疫疗法策略的局限性.
主要方法:
- 使用Z-scheme和Schottky接触器制造一个基于石的三元异质连接 (Bi@Bi2O3-Pt-PEG,BBOP).
- 使用BBOP进行超声触发声催化,以产生ROS并诱导PANoptosis和ICD.
- 调查BBOP对氧气供应和缺氧缓解的催化酶类活性.
- 在体外和体内实验,以评估抗瘤疗效和免疫激活.
- RNA测序以阐明治疗机制.
主要成果:
- 在超声波下,BBOP表现出增强的声触媒活性和ROS产量.
- 该物质有效诱导了PANoptosis和ICD,导致显著的瘤生长抑制和减少转移.
- Pt纳米酶活性提供氧气,缓解瘤缺氧,并抑制免疫反应.
- 在体内,BBOP成功地激活了抗瘤免疫反应.
结论:
- 通过增强ROS生成和诱导双细胞死亡途径,BBOP作为癌症免疫治疗的有效声敏剂.
- 开发的材料克服了瘤缺氧和免疫抑制,为声免疫治疗提供了一个有前途的策略.
- 这项工作为优化声敏剂和推进临床癌症治疗策略提供了基础.
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