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在千赫兹频率脉冲刺激下,喷氧化神经微电极的稳定性

Jimin Maeng¹, Rebecca A Frederick², Behnoush Dousti³

¹Qualia Oto, Inc., Dallas, TX, United States of America.

Journal of neural engineering

|November 18, 2024

概括

喷射氧化膜 (SIROF) 微电极在高频 (10 kHz) 神经刺激方面表现出卓越的稳定性和电化学性能. 这些发现支持它们在需要先进神经调节的慢性疼痛疗法中的应用.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
神经科学是一个神经科学.

背景情况:

千赫兹 (kHz) 频率刺激是一种有前途的神经调节技术,用于通过脊髓和外围神经块来治疗慢性疼痛.
关于高频刺激对电极材料性能的影响的研究有限,这对治疗疗效和安全至关重要.
喷射氧化膜 (SIROF) 微电极是由于其电化学特性而成为神经刺激的候选者.

研究的目的:

为了评估SIROF微电极在kHz频率脉冲电刺激下的电化学特性和长期稳定性.
确定SIROF微电极对于高频神经刺激应用的适用性.

主要方法:

在SIROF微电极中,使用频率在1.5到10kHz之间进行脉冲电刺激.
在单极和双极两种配置中,在电荷密度为250-1000μC cm−2 (25-100 nC阶段−1) 的情况下进行刺激.
电化学行为和稳定性使用电压过渡,循环电量计和电化学阻抗光谱进行了评估.

主要成果:

电极极化随着更高的刺激频率而增加,双极配置显示出比单极更大的极化.
在大多数测试条件下,潜在的外出仍在氧化水窗内 (-0.6到0.8V与AgAgCl相比).
在高达10kHz的频率下,SIROF微电极在超过109次脉冲后,电化学性能呈现最小的降解.

结论:

SIROF微电极稳定且电化学可行,可提供高频神经刺激高达10kHz.
这些微电极可以在缓冲盐水中以250-1000μC cm−2的电荷密度工作,支持它们在神经调节疗法中的使用.
这些发现验证了SIROF作为适用于需要高频电刺激的先进慢性疼痛治疗的合适材料.

关键词:

在SIROF中,SIROF是SIROF.千赫兹频率刺激的千赫兹频率刺激微电极阵列是一个微电极阵列.神经刺激的神经刺激喷的氧化物是氧化物.

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