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优化用于罕见疾病的3D打印药物:在直接粉末挤出3D打印中进行直线质量均性测试

Gloria Mora-Castaño1, Lucía Rodríguez-Pombo2, Paola Carou-Senra2

  • 1Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Universidad de Sevilla, Seville 41012, Spain.

International journal of pharmaceutics
|November 18, 2024
PubMed
概括

通过将平衡器集成到打印机中进行实时质量均性测试,提高了3D打印生物药物 (printlets) 的质量控制. 这确保了对生物丁酶缺乏治疗的精确剂量,这对于个性化医学至关重要.

关键词:
3D打印的药品可以使用3D打印.增材制造 增材制造是一种增材制造.药物输送系统,修改释放配方等.儿科的精密治疗方法药房的墨水 - 药房的墨水罕见的代谢障碍 罕见的代谢障碍

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...