胸内血管大动脉修复 vs 开放式手术修复后的心脏重塑和抗高血压药物变化
Karen Yuan1, Vamsi K Potluri1, Akshita Gorantla1
1Division of Vascular Surgery and Endovascular Therapy, Loyola University Chicago Stritch School of Medicine, Maywood, IL.
Journal of vascular surgery
|November 18, 2024
概括
胸内血管大动脉修复 (TEVAR) 可能会增加大动脉硬,导致更多的抗高血压药物与开放式手术修复 (OSR) 相比. 然而,心脏重塑在两种手术之间没有显著差异.
科学领域:
- 心血管外科心血管外科
- 血管医学 血管医学
- 大动脉疾病管理管理
背景情况:
- 心血管并发症是胸前大动脉修复后死亡的主要原因.
- 输内移植部署后大动脉硬度增加与不良的心脏变化有关.
- 与胸内血管大动脉修复 (TEVAR) 相比,开放式手术修复 (OSR) 的血液动力学影响不太了解.
研究的目的:
- 为了比较TEVAR和OSR后的心血管和血液动力学变化.
- 研究大动脉修复方法对大动脉硬性和心脏功能的影响.
主要方法:
- 对100名患有胸前大动脉动脉瘤或剖析的患者进行了回顾性分析.
- 50名患者接受了OSR,50人接受了TEVAR.
- 胸外心电回声评估了心脏功能;抗高血压药物变化作为血液动力学变化和大动脉硬性的替代标记.
主要成果:
- 12,24或36个月后,TEVAR和OSR之间的药物数量或剂量没有显著差异.
- 在调整人口统计数据后,TEVAR患者的抗高血压药物增加的可能性更高 (IRR,1.131;P=.044).
- 在TEVAR和OSR后观察到β-阻断剂和利尿剂的使用增加;左心室喷射率或过度缩没有显著差异.
结论:
- TEVAR与抗高血压药物升级的可能性更大,这表明大动脉硬度增加.
- 在TEVAR和OSR组之间没有发现心脏重塑的显著差异.
- 需要改善术后心脏监测和开发更兼容的大动脉移植来减少长期心血管并发症.
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