莱普水平与晚期前列腺癌患者的冠状动脉化有关
Efstratios Koutroumpakis1, Neha Venkatesh2, Ana Aparicio3
1Department of Cardiology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States.
患有晚期前列腺癌的男性患冠状动脉心脏病 (CHD) 的比例很高. 较高的瘦素水平,肥胖的一个标志物,与冠状动脉化有关,这表明前列腺癌和心血管风险之间存在联系.
科学领域:
- 心血管医学 心血管医学
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 汇聚的数据表明,晚期前列腺癌和冠状动脉心脏病 (CHD) 之间存在共同的生物脆弱性,可能与肥胖有关.
- 瘦素是脂肪的标记物和调解物,被认为是前列腺癌和心血管疾病之间的潜在联系.
研究的目的:
- 在患有转移性割抵抗性前列腺癌 (mCRPC) 的男性中,研究勒普丁水平与冠状动脉化 (CAC) 之间的关联.
- 为了确定丁水平是否与冠状动脉样硬化在这个患者群体中独立相关.
主要方法:
- 一项II期临床试验 (NCT02703623) 招募了mCRPC患者,这些患者接受了基剥夺疗法,阿比拉,普雷尼松和阿帕胺.
- 收集了血样本和胸部CT扫描以测量阿迪波金水平和冠状动脉 (CAC) 评分.
主要成果:
- 该研究包括164名患者,其中88%的患者超重或肥胖. 观察到CHD的高负担,70%的患者显示冠状动脉化.
- 莱普水平与右冠状动脉 (RCA) CAC评分正相关.
- 较高的瘦素水平,年龄较大和高脂血症独立地与RCA化和更多的化冠状动脉有关.
结论:
- 患有mCRPC的男性表现出显著的冠状动脉心脏病负担.
- 升高的丁水平与mCRPC男性的冠状动脉样硬化有关,独立于传统的心脏风险因素.
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