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在早产婴儿出生时凝血测定结果:一项队列研究强调了当地参考值对解释的相关性
Nina Houben1,2, Suzanne Fustolo-Gunnink2, Camila Caram-Deelder3
1Division of Neonatology, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, the Netherlands.
Vox sanguinis
|November 18, 2024
概括
出生时的凝血测试结果对于极度和非常早产婴儿来说是相似的. 然而,这些结果往往不同于既定的参考范围,突出了对NICU特定校准的需求.
科学领域:
- 新生儿医学 新生儿医学
- 血液学 血液学 血液学
- 儿科重症监护室的儿童重症监护室
背景情况:
- 新生儿重症监护室 (NICU) 的常规凝血查对早产婴儿提出了解释挑战.
- 由于不同的分析仪和试剂,局部凝血试验结果与公布的参考范围之间存在差异.
研究的目的:
- 评估进入新生儿重症监护室的非常早产婴儿生命第一天的凝血测定结果 (前热血素时间和激活的部分血栓塑时间).
- 为了比较极度早产 (<28周妊娠年龄) 和非常早产 (28-32周妊娠年龄) 婴儿之间的凝血测定结果.
主要方法:
- 在出生后24小时内对早产婴儿 (GA<32周) 的凝血试验 (PT和APTT) 的回顾性分析.
- 排除患有重大腹腔内出血或先前血输血的婴儿.
- 极早和极早组之间的凝血结果的比较.
主要成果:
- 在极度早产 (18.1s PT,44.2s APTT) 和非常早产 (18.7s PT,47.7s APTT) 婴儿之间观察到类似的中位数前热血素时间 (PT) 和激活的部分血栓形成时间 (APTT) 值.
- 凝血测定结果显示,与一些公布的参考范围有相当大的偏差.
结论:
- 出生时的凝血测定结果在极度和非常早产婴儿之间是可比的.
- 与参考范围的偏差表明需要对凝血设备和试剂进行NICU特定校准.
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