不响应性乳病的患病率和病因:系统审查和元分析
Nishant Aggarwal1, Unnati Bhatia1, Vignesh Dwarakanathan2
1Department of Internal Medicine, William Beaumont University Hospital, Royal Oak, Michigan, USA.
Journal of gastroenterology and hepatology
|November 18, 2024
概括
大约22%的患有乳病 (CeD) 的患者可能对无质饮食 (GFD) 没有反应,这种情况被称为无反应性乳病 (NRCD). 无意中暴露于质是NRCD患者持续症状的最常见原因.
科学领域:
- 胃肠病学 胃肠病学
- 临床医学 临床医学
- 饮食科学 饮食科学
背景情况:
- 非响应性腹病 (NRCD) 影响患有腹病 (CeD) 的患者,尽管坚持无质饮食 (GFD),但继续出现症状.
- 在现有文献中,NRCD的患病率和病因报告不一致.
- 为了澄清这些方面,进行了系统审查和元分析.
研究的目的:
- 为了确定CeD患者中NRCD的综合流行率.
- 识别和量化NRCD的常见原因.
主要方法:
- 原始研究的系统审查和元分析.
- 搜索了包括PubMed,Embase,Cochrane图书馆,Scopus和Web of Science在内的主要数据库.
- 遵循了流行病学观察性研究的元分析 (MOOSE) 准则.
主要成果:
- NRCD的综合患病率为22% (95% CI: 11-35%),影响了大约五分之一的CeD患者.
- 意外接触质是NRCD的主要原因 (33%).
- 功能性胃肠道疾病 (16%) 和耐火性CeDII型 (7%) 也是重要原因.
结论:
- 相当大比例的CeD患者可能会对GFD没有反应.
- 通过改善粘附性和新的治疗方法来解决无意中暴露于质的情况至关重要.
- 对管理NRCD的进一步研究是有必要的.
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