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相关概念视频

Types of RNA01:20

Types of RNA

5.7K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
5.7K
Translational Regulation01:29

Translational Regulation

1
Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
1
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

873
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
873
Regulated mRNA Transport02:22

Regulated mRNA Transport

6.2K
In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
6.2K
RNA Interference01:23

RNA Interference

25.9K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
25.9K

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相关实验视频

Updated: Jun 7, 2025

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture
10:34

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture

Published on: July 22, 2016

23.6K

非编码RNA标记,法规和互动资源.

Mengwei Cheng1, Yinhuan Zhu1,2, Han Yu1

  • 1College of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou, 325060, China.

Functional & integrative genomics
|November 18, 2024
PubMed
概括
此摘要是机器生成的。

本综述介绍了非编码RNA (ncRNA) 的统一符号系统,并探讨了它们的复杂相互作用. 它旨在标准化ncRNA及其在基因调节中的作用的研究.

关键词:
生物信息学资源资源互动组互动组是一个互动组.没有编码的RNA.标注 标注 标注 标注

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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

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iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution
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iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

Published on: April 30, 2011

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相关实验视频

Last Updated: Jun 7, 2025

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture
10:34

Detection of RNA-binding Proteins by In Vitro RNA Pull-down in Adipocyte Culture

Published on: July 22, 2016

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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA
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Identification of RNAs Engaged in Direct RNA-RNA Interaction with a Long Non-Coding RNA

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iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution
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iCLIP - Transcriptome-wide Mapping of Protein-RNA Interactions with Individual Nucleotide Resolution

Published on: April 30, 2011

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科学领域:

  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 非编码RNAs (ncRNAs) 越来越多地被认可为它们在基因表达和细胞调节中的作用.
  • 尽管进行了广泛的研究,但许多ncRNA的功能仍然没有特征,这凸显了对标准化研究方法的需求.
  • ncRNA研究领域正在迅速发展,需要不断开发识别和功能注释方法.

研究的目的:

  • 建议为ncRNAs提供统一的标记系统,以标准化研究.
  • 提供ncRNA互动组及其分子关联的全面概述.
  • 介绍一个网络门户,ncRNA Hub,作为ncRNA信息和生物信息学工具的集中资源.

主要方法:

  • 对非编码RNA研究的历史回顾.
  • 为ncRNAs开发一个统一的标记系统.
  • 通过文献综合和数据集成来阐明ncRNA互动组.
  • 构建ncRNA Hub网络门户网站.

主要成果:

  • 已经描述了50多种ncRNA类型,每个都有不同的功能.
  • ncRNA互动组涉及与DNA,RNA,蛋白质,复合体和染色质的复杂关联.
  • 该ncRNA中心 (https://bis.zju.edu.cn/nchub/) 提供标准化符号和生物信息学资源.

结论:

  • 统一的框架和标记系统对于推进非编码RNA研究至关重要.
  • 了解ncRNA互动组是解读它们的调节作用的关键.
  • 该ncRNA中心为该领域的研究人员提供了宝贵的资源.