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一种协生混合物用于婴儿结肠的管理:一个随机试验
Hanne Delcourt1, Koen Huysentruyt1, Yvan Vandenplas2
1Vrije Universiteit Brussel (VUB), UZ Brussels, KidZ Health Castle, Laarbeeklaan 101, 1090, Brussels, Belgium.
European journal of pediatrics
|November 18, 2024
概括
一种协生菌在一周内显著改善了婴儿的症状和护理人员的生活质量. 这种治疗证明了不论婴儿养类型的疗效,为结肠疾病的婴儿提供了快速缓解.
科学领域:
- 儿科 儿科 儿科
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 婴儿结肠的特点是婴儿长时间,无法安慰的哭泣.
- 虽然一些益生菌在母乳养的婴儿中表现出有效性,但对协生菌的证据较少.
- 护理人员的生活质量受到婴儿的重大影响.
研究的目的:
- 为了评估一种特定的共生菌 (Bactecal D液体) 在治疗婴儿结肠方面的疗效.
- 评估协生菌对护理人员生活质量和婴儿哭泣症状的影响.
- 为了比较每天服用一次和每天服用两次共生菌的有效性.
主要方法:
- 一项随机试验涉及68名被诊断患有可能婴儿结肠的婴儿.
- 婴儿在28天内每天服用一剂或两剂共生菌.
- 主要结局:护理人员的生活质量 (利克尔特尺度);二次结局:哭泣发作,哭泣时间,气体和身体痛苦指标.
主要成果:
- 从基线到28日,护理人员生活质量得分显著改善 (p < 0.001).
- 在干预后一周内,观察到生活质量的显著改善.
- 婴儿哭泣的情节,哭泣时间,气体和"拳头"在28日显著减少 (p < 0.001).
- 在每天一次和每天两次剂量之间没有发现有效性的显著差异.
结论:
- 测试的共生菌在治疗婴儿结肠方面是有效的.
- 在七天内观察到快速改善症状和改善护理人员的生活质量.
- 协生菌的益处独立于婴儿养方法 (母乳养,配方奶粉或混合).
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