临床实践中的简单测量可以作为 sarcopenic 肥胖症的代理并确定死亡风险吗?
Valdete Regina Guandalini1,2, Patrícia Silva Tofani2,3, Sara Souza Lima2
1Nutrition and Health Postgraduate Program, Federal University of Vitoria, Vitoria, Brazil.
Aging clinical and experimental research
|November 18, 2024
概括
标记性肥胖症,定义为肌肉质量低和腹部肥胖症,在50岁以上的成年人中,显著增加了83%的死亡风险. 通过简单的临床测量,可以识别这种高风险组进行干预.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 临床医学 临床医学
背景情况:
- 以肌肉损失和脂肪增加为特征的sarcopenic肥胖是一个公认的死亡风险因素.
- 由于对sarcopenic肥胖的不同定义,存在相互矛盾的结果.
- 这项研究解决了需要明确,临床上适用的定义的需求.
研究的目的:
- 用简单的临床测量来确定低肌肉质量和腹部肥胖是否预测50岁以上个体的死亡风险.
- 调查低肌肉质量和腹部肥胖对死亡率的独立和联合影响.
主要方法:
- 在14年时间内对5,440名参与者进行了长度研究,这些参与者来自英国长度研究老龄化.
- 由腰围定义的腹部肥胖;通过低骨肌肉质量指数 (SMMI) 定义的低肌肉质量.
- 考克斯回归模型分析了四个组的死亡风险:NLMM/NAO,NLMM/AO,LMM/NAO和LMM/AO.
主要成果:
- 低肌肉质量和腹部肥胖 (LMM/AO) 的组合增加了83%的死亡风险 (HR:1.83).
- 低肌肉质量 (LMM) 仅仅增加了40%的死亡风险 (HR: 1.40).
- 仅腹部肥胖 (AO) 没有与增加的死亡风险显著相关 (HR:1.09).
结论:
- 识别肌肉质量低和腹部肥胖 (LMM/AO) 个体对于预测老年人死亡风险至关重要.
- 简单,易于测量的参数可以有效地作为sarcopenic肥胖症的代理.
- 这些发现支持对高风险个体的早期干预策略.
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