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以生理学为基础的药理动力学建模,以评估里托纳维尔-迪戈辛相互作用,并为联合管理方案提出建议

Youjun Chen1,2, Wenxin Shao1,2, Xingwen Wang1,2

  • 1Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, Wuhu, 241001, Anhui, China.

Pharmaceutical research
|November 18, 2024
PubMed
概括

利托纳维尔显著增加了狄戈辛水平,造成毒性风险. PBPK建模建议将狄戈辛剂量减少45%或将间隔翻一番,以安全地管理这种药物相互作用.

关键词:
在PK-sim®中使用PK-sim®.消毒素 (Digoxin) 是一种消毒剂.药物相互作用 (DDI) 是一种药物相互作用.基于生理学的药理动力学 (PBPK) 模型.里托纳维尔 (ritonavir) 是一种药物.

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