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在结直肠癌进展中对染色体外圆形DNA进行全面的分析

Lu Lu^1,2, Mingjie Chen³, Guicheng Zhang³

¹China-Canada Center of Research for Digestive Diseases (ccCRDD), Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Xuhui District, Shanghai, 200032, China.

Scientific reports

|November 18, 2024

概括

外染色体圆形DNA (ecDNA) 在结直肠癌 (CRC) 进展中起作用. 一种特定的ecDNA,chr8 ecDNA 64950741-114379093,在CRC上调节,与预后不佳有关,表明其作为生物标志物的潜力.

科学领域:

基因组学就是基因组学.
癌症生物学癌症生物学
分子瘤学分子瘤学

背景情况:

结肠直肠癌 (CRC) 是由结肠直肠表皮的分子变化引起的.
外染色体圆形DNA (ecDNA) 参与癌症基因组重塑,但其在CRC中的作用尚不清楚.

研究的目的:

在结直肠癌连续体中全面描述圆形DNA和转录组.
确定关键的ecDNA和相关途径,参与CRC的发展和进展.

主要方法:

采用循环测序和整个转录基因测序.
分析了来自健康个体,结肠直肠腺瘤和CRC患者的样本.
在50名CRC患者的独立队列中验证了这些发现.

主要成果:

在CRC进展过程中,特征性ecDNA驱动瘤基因表达.
确定了免疫反应和细胞循环途径作为CRC中的主导事件.
在CRC中观察到chr8ecDNA64950741-114379093的显著上调,与预后不佳相关.

结论:

提供了对结直肠癌中的ecDNA景观的新见解.
突出显示 chr8 ecDNA 64950741-114379093 作为潜在的生物标志物和治疗瘤治疗的治疗目标.

关键词:

生物标志物生物标志物在CRC的进展过程中,CRC的进展过程.圆形的 DNA 是一个圆形的 DNA.chr8 ecDNA 64950741 114379093 114379093 114379093 114379093 114379093 114379093 114379093 114379093 114379093 114379093 114379093 114379093 114379093 114379093 114379093 11437909093 114379093 11437909093 11437909093 11437909093 11490909093 11490909093 11490909093 11490909093 1149090909093 1149090909093 1149090909093 1149090909093 1149090909 1

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