对Pb,Cd,Hg,Se,Cu和Zn的单次和联合暴露与老年人的认知功能有关
Zixuan Fu1,2, Xiaofang Xu1,2, Li Cao1,3
1MOE Key Laboratory of Coal environmental pathopoiesis and control, Shanxi Medial University, Taiyuan, 030001, China.
Scientific reports
|November 18, 2024
概括
对,,,,,铜和的联合暴露会影响老年人的认知功能. 联合暴露显示了与认知测试的混合关联,突出了复杂的健康影响.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
背景情况:
- 由于接触重金属而导致认知功能受损是一个日益严重的全球健康问题.
- 结合重金属暴露对认知的影响尚不清楚.
研究的目的:
- 调查多重金属暴露与认知功能之间的关联.
- 为开发预防重金属诱导认知衰退的预防策略提供证据.
主要方法:
- 在811名美国老年人的血液中分析了 (Pb), (Cd), (Hg), (Se),铜 (Cu) 和 (Zn) 的含量 (NHANES 2011-2014).
- 使用量子回归,受限立方线和贝叶斯核机器回归.
- 使用物件响应理论 (IRT),延迟回忆测试 (DRT),动物流利性测试 (AFT) 和数字符号替代测试 (DSST) 评估认知功能.
主要成果:
- (Cd) 与IRT.显示出负相关性.
- (Se) 和 (Zn) 分别与DSST和IRT有积极的关联.
- 铜 (Cu) 与DSST有负相关性. 对所有六种金属的联合暴露与认知测试有混合的线性关联,Cd与其他金属之间有显著的相互作用.
结论:
- 暴露于,,,,,铜和与认知功能有关.
- 对这些重金属的联合暴露表明了与不同认知能力的复杂关联,包括与IRT和DRT的积极联系,以及与DSST的负面联系.
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