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Updated: Jun 7, 2025

Detection of Post-Replicative Gaps Accumulation and Repair in Human Cells Using the DNA Fiber Assay
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Published on: February 3, 2022

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CAF-1促进了对新生DNA的高效PrimPol招募,用于单链DNA间隙形成

Joshua Straka1, Jude B Khatib1, Lindsey Pale1

  • 1Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Nucleic acids research
|November 18, 2024
PubMed
概括

CAF-1-ASF1通路促进在复制分叉处单链DNA (ssDNA) 间隙积累,影响同源重组 (HR) 缺陷瘤中的化学敏感性. 这个过程依赖于CAF-1

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