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Updated: Jun 7, 2025

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RAS信号通路对于调节PIEZO1介导的肝脏铁过载在脱水遗传性胃细胞瘤中至关重要

Barbara Eleni Rosato1,2, Vanessa D'Onofrio1,2, Roberta Marra1,2

  • 1Department of Molecular Medicine and Medical Biotechnologies, "Federico II" University of Naples, Naples, Italy.

American journal of hematology
|November 18, 2024
PubMed
概括

获得功能的PIEZO1变体通过通过肝细胞的RAS信号激活来抑制肝素素,从而导致铁过载. 抑制这种途径会恢复肝素,为脱水遗传性胃细胞瘤提供潜在的治疗点.

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