DAPK通过抑制TRIM25介导的基于ubiquitination的DDX20降解来增强DDX20蛋白的稳定性

Yan Ye1,2,3, Xiuli Zhang1,2, Chenyi Wang4

  • 1College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, Fujian, China.

Cancer cell international
|November 18, 2024
PubMed
概括

与死亡相关的蛋白激酶 (DAPK) 通过抑制TRIM25介导的降解来稳定DDX20,抑制肝细胞癌 (HCC) 细胞入侵. 这揭示了HCC药物开发的新DAPK-TRIM25-DDX20轴.

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