分析预后并比较COVID-19肝硬化患者死亡率的预测评分系统:一个多中心的回顾性研究
Shou-Yen Chen1,2, Chip-Jin Ng1, Yan-Bo Huang1
1Department of Emergency Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 5 Fushing St., Gueishan Shiang, Taoyuan, 333, Taiwan.
BMC infectious diseases
|November 18, 2024
概括
这项研究发现,世卫组织的顺序尺度最能预测COVID-19肝硬化患者的死亡率. 凝血,输管和德克萨米他的使用是关键的预后因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 肝硬化是严重的COVID-19的一个独立风险因素.
- 肝硬化患者面临更高的住院和COVID-19死亡率.
- 有限的研究存在于COVID-19在肝硬化中的预后因素.
研究的目的:
- 确定COVID-19肝硬化患者死亡率的预后因素.
- 验证现有的评分系统,以预测住院死亡率.
- 确定这个患者群体的最佳评分系统.
主要方法:
- 对1368名成年COVID-19肝硬化患者进行了回顾性队列研究.
- 从电子健康记录提取的数据 (2021年4月 - 2022年9月).
- 分析了住院死亡率,并评估了世卫组织顺序尺度,MELD和MELD-Na得分.
主要成果:
- 不幸存者具有较低的生命体征和较高的炎症标志物 (WBC,CRP, bilirubin).
- 不幸存者显示出更长的前列血时间和更高的输管和使用德克萨的率.
- 世卫组织的顺序尺度,MELD和MELD-Na得分显示出对死亡率的良好预测能力.
结论:
- 世卫组织的顺序尺度是COVID-19肝硬化患者死亡率的最有效预测指标.
- MELD和MELD-Na得分也显示出死亡率预测的良好表现.
- 凝血功能,输管和德克萨米他是显著的预后因素.
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