较高的血清25-氧维生素D水平是否会损害骨矿物质密度? :一个横截面研究
Bingcheng Xu1, Qiai Li2, Bo Luo1
1Department of Geriatrics, Wuhan Wuchang Hospital, Wuhan, 430063, China.
BMC endocrine disorders
|November 18, 2024
概括
对于骨健康的最佳维生素D水平因性别而异. 对于男性来说,84.8nmol/L是理想的,而女性需要超过31.4nmol/L来支持骨矿物质密度 (BMD).
科学领域:
- 内分泌学和骨代谢 骨质代谢
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 维生素D对于骨健康和骨质疏松症管理至关重要.
- 维护骨矿物质密度 (BMD) 的最佳维生素D补充策略仍在争论中.
- 这项研究研究了血清25-基维生素D [25(OH) D]和成人骨硬化之间的关系.
研究的目的:
- 确定大量成年人群中血清25(OH) D水平和总骨质量之间的相关性.
- 为了确定特定于性别的最佳血清25(OH) D值,以确保骨健康.
主要方法:
- 分析了2011-2018年国家健康和营养检查调查 (NHANES) 的11,375名成年参与者的数据.
- 关键的变量包括血清25(OH) D水平和骨质量.
- 用多变量逻辑回归来控制混因素.
主要成果:
- 在血清25(OH) D和BMD之间观察到U形的关联.
- 在男性中,与BMD的正相关性在84.8nmol/L以下显著 (p < 0.0001).
- 在女性中,与BMD的正相关性在31.4nmol/L以下显著 (p = 0.0010),在这个水平以上显著性下降.
结论:
- 成年男性的最佳血清25(OH) D水平为84.8nmol/L;更高的水平不会增强BMD.
- 对于成年女性来说,血清25(OH) D水平应高于31.4nmol/L以支持BMD.
- 维持足够的维生素D水平对于男性和女性的骨健康至关重要.
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